The whole world celebrates this article: discover the cure for Lupus.

Lupus is a chronic autoimmune disease that can damage any part of the body, from the skin to the joints through the organs. It is a disease that acts by outbreaks and then seems to disappear before returning again.

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But researchers say they have discovered that by using a combination of two drugs already exist, it is possible to reverse the effects of lupus in mice.

In a new study published in Science Translational Medicine, researchers at the University of Florida, Gainesville, have discovered that by inhibiting certain metabolic pathways in immune cells that can fight lupus in mice. Researchers at UF Health may have found a way to control lupus changing the way the immune system cells use energy.
“The most surprising result of this study was that the combination of the two metabolic inhibitors were needed to reverse the disease.” Dr. Laurence Morel, University of Florida College of Medicine

Systemic lupus erythematosus or lupus, is an autoimmune disease in which the immune system that is supposed to protect the body against foreign invaders – attacks the body’s own tissues, causing inflammation. Lupus can sometimes have symptoms similar to arthritis.
One of the markers of lupus are CD4 T cells (white blood cells that activate other immune cells). For people with lupus, the metabolism of T cells is overactive. T cells activated involve hyper- increased inflammation, and this means more physical damage. When researchers blocked glucose metabolism by using an inhibitor of glucose, metformin (common treatment in type 2 diabetes), CD4 T cells return to normal activity (metabolism CD4 slows down) and lupus symptoms were reversed. “If the T cell is normal, the disease gets better,” Morel said.
The research team initially had the idea of using a two-pronged attack on lupus after seeing a similar approach in research in cancer, said Dr. Laurence Morel, director of experimental pathology and professor of pathology, immunology and medicine laboratory in the UF College of Medicine.
“If it works to limit the metabolism of cancer cells, should work to limit metabolism in T cells,” said Dr.Morel.
The efficacy of metformin in restoring normal function of T cells when studied in the laboratory is also bode well for potential future application for the treatment of patients with lupus.
“That suggests that metabolic inhibitors can also be used to treat patients,” Morel said. “It’s the first time has shown that it can have an effect on the symptoms and manifestation of lupus by normalization of cellular metabolism.”
The two used in research in this study drugs were shown to inhibit the metabolic pathways before, but the combination seems to be the key to success.
“The most surprising result of this study was that the combination of the two metabolic inhibitors were needed to reverse the disease, when they could have predicted, based on models published by other people that one would work,” said study co-author ,
Dr.Laurence Morel, director of experimental pathology and professor of pathology, immunology and laboratory medicine at the University of Florida College of Medicine.
Among other researchers who worked on the project are: Dr. Eric S. Sobel, associate professor of rheumatology and clinical immunology professor; Dr. Byron P. Croker, a professor of renal and surgical pathology; and Dr. Todd Brusko, assistant professor in the UF Diabetes Institute, department of pathology, immunology and medical laboratory.
Their research was funded by grants from the National Institutes of Health and the Alliance for Lupus Research. The human trial will be made in September 2015, favorable results are expected since the tests in mice was a success.

Source: Federalstudyresearch.com

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Michael B. Jordan Encourages Selena Gomez as She Takes Time Off for Her Mental Health

 michael-b-jordan-selena-gomez-lede-750x375“Stay optimistic, don’t succumb to how you feel in the moment.”

Dealing with a chronic illness is so tough in so many ways, but many people often don’t realize the toll it can take on someone’s emotional and mental health. When Selena Gomez cancelled the rest of her Revival tour to focus on her mental well-being, she made it very clear that her lupus has many effects that aren’t physical. She noted that anxiety and depression are side effects of having the condition, and she also made it clear that she needs and deserves time to properly deal with those effects. Selena is right, and her friend Michael B. Jordan is here to back her up.

Refinery 29 reports Michael spoke up about Selena taking time off to care for her mental well-being, saying it’s a totally necessary step. Michael knows because he witnessed his mother, who also has lupus, go through the same thing.

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“Everybody comes to terms with it in their own time, and she’s finally taking the time to deal with it and address it,” Michael said to Entertainment Tonight. “My advice would be: Stay optimistic, don’t succumb to how you feel in the moment — because it will pass and get better — and surround yourself with positive people.”

After Selena talked about the mental health impacts of having a chronic disease, Teen Vogueasked author and patient advocate Ashley Boynes-Shuck what the connection between the two is. Ashley, who goes by Arthritis Ashley online, told us being diagnosed with an incurable illness can absolutely impact someone’s mental well-being.

“The emotional components of rheumatic diseases such as lupus are vast and varied. Recent studies have shown that patients with diseases like rheumatoid arthritis, which is similar in nature to lupus, often deal with decreased cognitive function as well as being predisposed to extreme mood disorders,” Ashley says. “Studies also show a link between these types of disorders and serotonin deficiency, which can be associated with depression. It is difficult for anyone to cope with an incurable lifelong illness, but I would imagine that it would be even more difficult to do while being in the spotlight.”

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Michael backed that up when he was talking to Entertainment Tonight.

“Just coming to terms with the fact that she’s not healthy, and there’s no cure for it, is really hard,” Michael said. “So you have to be extremely optimistic about finding a cure.”

Michael suggested Selena surround herself with supportive people. It sounds like he’s the best person she could be around.

SOURCE: teenvogue.com

 

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how Lupus effects Your Skin?

The skin is often affected by lupus, and plays a very important role in diagnosing the illness—whether it’s the skin-only form—cutaneous lupus erythematosus—or the body-wide “systemic” lupus erythematosus.

Common types of cutaneous lupus include chronic cutaneous lupus, which often involves thick and scaly red “discoid” rash lesions and patchy hair loss, and acute cutaneous lupus, which often involves a malar “butterfly-shaped” rash across the cheeks and nose and in some cases the development of fluid-filled “bullous” lupus lesions.

In systemic lupus, the body’s overactive immune system forms antibodies that attack and damage not just the skin but other crucial tissues and organs such as the kidneys, heart, lungs, blood and joints. Four of the 11 official criteria for systemic lupus are skin-related: malar rash, discoid rash, sensitivity to sunlight (photosensitivity) and oral ulcerations.

Most people are anxious to know if something in their lifestyle or diet caused lupus. It’s still not clear why certain people get the disease, but both genes and environmental triggers likely play a role. Any blood relative with an autoimmune disease such as rheumatoid arthritis may pass along the genes that predispose a relative to lupus. And then environmental triggers cause the disease to develop and flare.

What kinds of things happen to the skin in lupus?
Lupus can cause a range of skin reactions that mimic other more common skin disorders, making diagnosis of the illness challenging in many cases. The “butterfly” rash may be mistaken for rosacea, psoriasis, or eczema, for example, and delay the right diagnosis as they initially improve with topical treatments.

Common skin reactions in lupus include:

  • Patches of red and raised “discoid” skin lesions on sun exposed areas such as the face and hands. Without treatment, discoid lesions often get worse. Prescription corticosteroid creams or injections can help eliminate them, and corticosteroid pills and anti-malarial drugs can be tried if the lesions don’t get better or are severe. But topical formulations are always tried first. A discoid rash on the scalp should be treated aggressively to prevent progression and permanent hair loss.
  • A red butterfly-shaped “malar” rash across the nose and cheeks. Apply a broad spectrum sunscreen to avoid or minimize these rashes, and corticosteroid ointments or gels as recommended by your doctor. Careful management of lupus in other parts of body also helps.
  • Loss of hair—strand by strand or in clumps. Sometimes hair loss is a direct result of the immune system activity destroying hair follicles, and can’t be stopped except through treatment for the lupus.
  • Sores in the mouth, on the tongue, in the nose, and (rarely) in the vagina. Gargle several times daily with buttermilk or hydrogen peroxide diluted in a few ounces of water to ease the pain and prompt healing. Topical and oral corticosteroids, as well as anti-malarial drugs can help. For nose sores, try dabbing on petroleum jelly.
  • Color (pigment) skin changes from dark or light can occur after lupus-related inflammation subsides, or anti-malarial or corticosteroid drugs are stopped. Cosmetics can be used to mask the color changes.
  • Hives or welts (urticaria) are typically treated with antihistamines, anti-serotonin drugs, and corticosteroids. If persistent it may signal vasculitis, an inflammation of the blood vessels that requires extra treatments.

Other common lupus-related skin problems include Raynaud’s phenomenon in which fingertips turn red, white and blue in reaction to cold temperatures, vasculitis with a breakdown of the skin from inflammation of vessels near the skin’s top layer, a red mottling or lacelike appearance under the skin called livedo reticularis, and the appearance of red or purple discolorations under the skin (purpura) caused by bleeding. Also, corticosteroid drugs commonly used to treat lupus can cause complications such as black and blue marks and skin thinning.

How can lupus skin scars be treated or covered up?
Filler and laser technology has exciting potential to improve scarring and pigment disturbances and may be less risky than plastic surgery in some people—but shoudln’t be done unless the disease is in full remission and by a doctor knowledgeable about these techniques and about lupus. Camouflage makeup, when properly blended and applied, can often completely conceal skin discoloration and scarring.

Avoiding sunlight is one of the most important things you can do if you have lupus.The sun’s UVB and UVA ultraviolet rays are major lupus triggers and that can prompt photosensitivity reactions 365 days a year—on cloudy as well as sunny days—and in as little time as it takes to walk to the corner store. UVB rays are normally associated with sunburn and tans. UVA rays, which are present in all seasons and from dawn until dusk, penetrate more deeply into the skin but don’t cause redness or burn, and are therefore less likely to be recognized as lupus flare triggers.

If I have cutaneous lupus, what are the chances that I will get systemic lupus?
Many people worry about this, but in fact only 1 in 10 people with cutaneous lupus develop the systemic form of the disease. By protecting yourself from environmental triggers such as sunlight and cigarette smoke, as well as keeping watch for so-called “Markers of Transition” to systemic lupus with the help of experienced doctors, you can help to prevent this serious transition and even possibly reverse its course if it starts.  The “markers” include the appearance of skin ulcers and calcium deposits and nodules under the skin, and the development of generalized joint and/or muscle pain, rash below the neck, and protein or blood in the urine.

Protect yourself from a lupus flare!

  • Apply broad-spectrum UVA-UVB protective sunscreen every day of the year. Choose a product with a Sun Protection Factor of 30 or higher and which contains avobenzone (Parasol 1789), titanium dioxide, and/or zinc oxide, as these provide the broadest protection against both UVA and UVB. A newer ingredient, mexoryl, is available in some sunscreens and is very effective against UVA. Slather on before makeup, and no less than 10 minutes before going outside.
  • Limit unnecessary outdoor activities—especially when the sun tends to be at its most intense between 10 AM and 3 PM—and invest in special sun-protective clothing and wide-brimmed hats.
  • To minimize exposure to UVA rays, place plastic over window glass and encase halogen lights and fluorescent bulbs in plastic casings. Use a polarizing guard over your computer screen. Flat screens, such as on laptops, do not require this precaution.
  • Check about the added risk for photosensitivity when taking certain medicines such as diuretics, antibiotics, anti-inflammatory drugs, and birth control pills.

source: lupusny