Addison’s Disease: The Fact Sheet- Drug rehab center

Addison’s disease is a severe or total deficiency of the hormones made in the adrenal cortex, caused by the destruction of the adrenal cortex. It is basically a hormonal disorder that occurs in all age groups and afflicts men and women equally.

This hormonal disorder affects about 1 in 100,000 people, but there are no accurate statistics on the incidence of Addison’s disease in the United States. Because these hormones produced by the adrenal gland give instructions to virtually every organ and tissue in your body, the effects of its’ deficiency are very serious!

 Adrenal glands and hormones

The adrenal glands are small organs located on top of each kidney. They consist of the:

* The outer portion –  the cortex and
* The inner portion – the medulla

The cortex produces 3 types of hormones:

1. sex hormones,
2. glucocorticoid hormones, and
3. mineralocorticoid hormones

Addison’s disease, no matter what has caused it, occurs when the adrenal glands do not produce as much of the hormones as it should normally produce. The disease is also called adrenal insufficiency or hypocortisolism. The two main hormones that adrenal gland is producing are cortisone and aldosterone!

    * Cortisol

Cortisol belongs to a class of hormones called glucocorticoids, which affect almost every organ and tissue in the body. Most of the experts believe that cortisol probably has hundreds of effects in the body.

Cortisol is also called the stress-hormone because its most important job is to help the body respond to stress. Some of the main functions is to help:

o maintain the blood pressure
o support the cardiovascular function
o slow the immune system’s inflammatory response
o balance the effects of insulin in breaking down sugar for energy
o regulate the metabolism of proteins, carbohydrates, and fats
o maintain the proper arousal and sense of well-being

Adrenal glands have many mechanisms for the precise and balanced production of this hormone because it is so vital to health.
The production of cortisone is regulated by the hypothalamus and the pituitary gland, similarly to the control of the thyroid hormones production.

First, the hypothalamus sends hormones to the pituitary gland, which then responds by secreting hormones that regulate growth and thyroid and adrenal function, and also the sex hormones such as estrogen and testosterone. Pituitary hormone that controls the adrenal glands is called ACTH – Adrenocorticotopic hormone.

    * Aldosterone

Aldosterone belongs to a class of hormones called the mineralocorticoids. One of its most important functions is to help maintain the blood pressure and the water and salt balance in the body. It does so by helping the kidneys retain sodium and excrete potassium.

We can easily understand that, when aldosterone production is too low, the kidneys are not be able to regulate salt and water balance, causing blood volume and blood pressure to decrease.

Symptoms of Addison’s disease

The symptoms of adrenal insufficiency usually begin gradually and some of the most common ones are:

* chronic, worsening fatigue
* muscle weakness
* loss of appetite
* weight loss
* nausea
* vomiting
* diarrhea
* darkening of the skin (hyper-pigmentation)
* low blood pressure and even fainting
* salt craving
* irritability and depression

Addisonian crisis

The bad thing about this condition is that, because the symptoms progress slowly, they are usually ignored until some stressful event causes them to become worse.
This is called an Addisonian crisis, or acute adrenal insufficiency. Symptoms of an Addisonian crisis include:

* sudden penetrating pain in the lower back, abdomen, or legs
* severe vomiting and diarrhea
* dehydration
* low blood pressure
* loss of consciousness

Causes of Addison’s disease

There are several possible causes of Addison’s disease and some of the most common are:

Primary Adrenal Insufficiency

Autoimmune theory tells that the most of the adrenal insufficiency cases are caused by the gradual destruction of the adrenal cortex by the body’s own immune system. This means that the immune system makes antibodies that attack the body’s own tissues or organs and slowly destroy them. Adrenal insufficiency occurs when at least 90 percent of the adrenal cortex has been destroyed. Possible causes of this type of deficiency are:

* Tuberculosis
* Other infections of the adrenal glands
* Spreadind of the cancer to the adrenal glands
* Bleeding into the adrenal glands

Polyendocrine Deficiency Syndrome

This is a very complex syndrome which comes in two different forms:

* Type I – affects children only and it is accompanied by the underactive parathyroid glands, slow sexual development, pernicious anemia, chronic Candida infections, chronic active hepatitis and, in rare cases, hair loss.
* Type II – often called Schmidt’s syndrome. It usually afflicts young adults and it is accompanied by an underactive thyroid gland, slow sexual development, diabetes, vitiligo and loss of pigment on areas of the skin.

Secondary adrenal insufficiency

Adrenal insufficiency can also occur if the pituitary gland is affected and doesn’t produce hormones properly. This will result in the lack of ACTH hormone, which stimulates the adrenal cortex to produce its hormones.
So, even though adrenal glands aren’t damaged, the inadequate production of ACTH can lead to insufficient production of hormones normally produced by adrenal glands. Secondary adrenal insufficiency can also occur when people are taking corticosteroids for treatment of some chronic conditions, such as asthma or arthritis, and then suddenly stop taking the medications.
Other possible reasons are:

* tumors or infections of the area
* loss of blood flow to the pituitary gland
* radiation treatment of pituitary tumors
* surgical removal of the parts of the hypothalamus
* surgical removal of the pituitary gland

Diagnosis of Addison’s disease

Some of the most common diagnostic tools used for a proper diagnosis of Addison’s disease are:

Blood test

It is performed by measuring the blood levels of sodium, potassium, cortisol and ACTH. This method gives doctor an indication on whether adrenal insufficiency may be causing the signs and symptoms a patient is experiencing. The blood test can also measure the amount of antibodies associated with autoimmune caused Addison’s disease.

ACTH Stimulation Test

This is the most specific test for diagnosing the Addison’s disease. During this test, cortisol in the blood and urine are measured before and after a synthetic form of ACTH is given by injection. Measurement of cortisol in blood is repeated 30 to 60 minutes after this injection. The normal response after an injection of ACTH is a rise in blood and urine cortisol levels. It is logical to assume that patients with adrenal insufficiency will respond poorly or do not respond at all.

CRH Stimulation Test

In this test, a synthetic cortisone releasing hormone (CRH) is injected intravenously. The blood cortisol levels are measured before the injection and  then 30, 60, 90, and 120 minutes after the injection.
The problem with the patients with primary adrenal insufficiency is that they have high ACTH but do not produce cortisol at all. On the other hand, the patients with secondary adrenal insufficiency have deficient cortisol responses but absent or delayed ACTH responses. This is because the exact cause of deficiency are the pituitary gland and hypothalamus.

Imaging tests

Some doctors recommend computerized tomography (CT) scan of the abdomen to check the size of your adrenal glands and look for other abnormalities that may give them the insight into the cause of the adrenal insufficiency. CT is a diagnostic tool that is very similar to common X-ray but it involves computer processing of the images. Some doctors may also suggest a CT scan or the magnetic resonance imaging scan of the pituitary gland if testing indicates that the patient has secondary adrenal insufficiency.

Treatment of Addison’s disease

Since all of the manifestations of Addison’s disease are caused by the lack of cortisol and aldosterone, the goal of the treatment is to replace or substitute these hormones with similar steroids.

Cortisol is replaced orally with hydrocortisone tablets, a synthetic glucocorticoid, taken once or twice a day. It is also replaced by using

* hydrocortisone (Cortef®),
* prednisone (Deltasone®) or
* synthetic cortisone.

If aldosterone is deficient, it is replaced with oral doses of a mineralocorticoid called fludrocortisone acetate (Florinef®), which is taken once a day.
Since an Addisonian crisis may represent a life-threatening situation that results in low blood pressure and high levels of sugar and potassium in the blood, this situation requires immediate medical treatment which includes intravenous injections of:

* Hydrocortisone
* Saltwater solution
* Sugar (dextrose)



Researchers Discover Cause of Eosinophilic Esophagitis- Advanced mold remediation

Researchers report that they have discovered the cause of eosinophilic esophagitis (EoE), a hard-to-treat food allergy. In EoE, large numbers of white blood cells, known as eosinophils, accumulate in the lining of the esophagus (the tube that connects the mouth to the stomach), causing chronic inflammation. Led by a team at Cincinnati Children’s Hospital, investigators have found a new genetic and molecular pathway in the esophagus. This discovery, reported online today inNature Genetics, opens the door to new therapies for EoE, which has been diagnosed in a growing number of children and adults over the past decade.

The study found that EoE is triggered by the interplay between epithelial cells, which help form the lining of the esophagus, and a gene called CAPN14. When the epithelial cells are exposed to an immune hormone called interleukin 13 (IL-13), which is known to play a role in EoE, they cause a dramatic increase in CAPN14. CAPN14 encodes an enzyme called calpain14, which is also part of the disease process. Because drugs can target calpain 14 and modify its activity, the study opens up new therapeutic strategies for researchers to explore.

“In a nutshell, we have used cutting-edge genomic analysis of patient DNA, as well as gene and protein analysis, to explain why people develop EoE,” says Marc E. Rothenberg, MD, senior investigator on the study. “This is a major breakthrough for this condition … Our results are immediately applicable to EoE and have broad implications for understanding eosinophilic disorders as well as allergies in general.” The study was funded, in part, by the National Institutes of Health (NIH), with additional support from other organizations, including FARE.



Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity-Drug rehab center

Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets.


Recent research has, however, indicated that the pathogenesis of EoE is distinct from IgE-mediated food allergy. In this review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the pathogenesis of EoE. Although food has been recognized as a trigger factor of EoE, the mechanism by which it initiates or facilitates eosinophilic inflammation appears to be largely independent of IgE and needs to be further investigated. Understanding the pathogenic role of food in EoE is a prerequisite for the development of specific diagnostic tools and targeted therapeutic procedures.



Throat Disease Eosinophilic Esophagitis (EoE) Affecting More Kids- Term life

Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus. Cases have risen dramatically in the past 20 years, say doctors, and there remains no cure for the disease.



I stood in my closet this morning, looking around as though I’d never been there. I couldn’t remember what I was doing, why, or what I should do next. So I stood still, waiting for it to come to me. Moments before I had been violently panting like a wild animal, bent over in pain and hugging my own body. I’d simply gone upstairs to get dressed for the day, but just as it does every day of my life in varying degrees, my illness reminded me who was in charge.

Tears welled up. That happens a lot, too. I don’t always have words any more when I want to express what I’m feeling so my soul expresses it for me. I forget. A lot.


I was first diagnosed with Fibromyalgia in my early 30s by a young doctor who had clearly just learned the word on a sleepover at Junior Doctor Camp.

“You will grow weaker and weaker until finally your muscles atrophy. Your life span will be drastically shortened, and you’ll live out your final years wheelchair bound.”

Over the years I would experience sporadic periods of improvement and so I’d decided that Fibromyalgia was a bullshit diagnosis, and I damn sure didn’t have it.

Then I’d get really sick again.


My arms and legs go numb, almost always both at the same time but sometimes not. Either way, I fall down, bump into things, lose my balance. I can’t always tell where my foot is hitting, and when that happens you would think that our floors are made of chewed up bubble gum.

My joints stiffen so severely that my ankles don’t want to bend and my elbows always feel like someone hit them with a hammer while I slept.

I move like Frankenstein, only not as gracefully.

My muscles ache down to the bone in a way that feels like I am always battling influenza. It never stops. Ever.

But, by far the worst thing I’ve been living with for so long is extreme fatigue. I’ve thought so often about what word I could possibly use to describe what it feels like, and I’ve always come up empty. All I can tell you is the kind of fatigue I live with every day is what I believe it must feel like to die. When it’s very bad, doctors notice a palsy that comes over my face, and I have trouble even standing. I can’t rest enough to recover. I say it’s like someone is embalming me.

That can happen whether I am sitting in a chair with my feet up, or it can happen after I’ve played with my grandmonkeys. It doesn’t matter what I do. It’s always there.

I’ve said to every doctor I’ve seen, “I know that I will not live much longer. I’m dying.” I’ve known that for a long time. In years past I’d have bursts of weeks or months of energy that would allow me to behave normally. But, I always knew I was dying. In the past three years I’ve really felt my life slipping away. There have been almost no bursts of energy or good days – just me waiting to go to sleep and not wake up.

I figured that in my autopsy results they’d discover what was really wrong with me and “the world” would know I wasn’t crazy. Well, at least as it pertains to my health.

Across decades I’ve been seen by new doctors, and with each came mounds of new medical bills. “You are presenting like you have MS,” they’d all say, and then after the same battery of tests came the same diagnosis.

Fibromyalgia and Chronic Fatigue Syndrome.

Fibromyalgia or toxic mold poisoning? -

“I don’t believe that either of those is a diagnosis,” I’d say to them. “You are labeling me with those words because I am a woman, and because you don’t know what else to do with me.”

Want to piss off a doctor? Tell them you think they don’t know what they’re talking about. One particularly cocky son-of-a-bitch said to me, “You seem like you’d rather I’d have said you have MS.”

I know people who suffer unspeakably with Multiple Sclerosis. It’s vicious. But, yes. Sometimes I’d have taken the diagnosis of that horrific disease if only to have a “real thing” that explains why I so often can’t walk the ten feet from my recliner to the closest bathroom without holding onto something. People believe you when you say you have MS. They understand (as best they can), that you’re not well and that you’re not a liar who is seeking attention.

It’s not the same mindset with regard to Fibro and CFS.

I remember someone I deeply respect who suddenly made a proclamation on Facebook about women and Fibromyalgia. Go on a diet, get some exercise and grow up pretty much sums up the sentiment. There was no way I could tell people how sick I’ve been for fear they’d think of me as someone who wasn’t trying hard enough to be healthy, or worse, have them think it was all in my head.

Vapors or Fibromyalgia? What's the difference?

Just to be sure, I went to see a psychiatrist. “Sher, you aren’t crazy. This isn’t in your head,” he said. To his credit he also said, “I could prescribe Lyrica for you, but if I do that it’s the same as saying I believe what you’ve been told about what’s going on and I don’t. You have to keep pushing until you get to the person who can help you.”

Well-meaning close friends and not so well-meaning relatives had more to say when I would take them into my confidence about how unwell I was. To be fair, there is only one person who knows how bad I am. Some people in my life know a little, and some a little more, but no one knows the extent of just how damn bad it’s been beyond my partner.


You need to cut out gluten. You need to cut out sugar. You need to push through it. You need to exercise. You should pray. You need to try harder to force yourself to do things that are uncomfortable. My friend knows someone who knows someone who has Fibromyalgia and they are living their life, not laying around letting it happen.

And the worst things that have been said? The things that I can’t get out of my head and that bring me to tears even as I write?

“Are you planning on being sick next month?”

“Seriously? Don’t tell me you’re sick again. Really? It’s funny how you’re sick when I need something from you.”


An acquaintance dropped me a note one day that encouraged me to see a infectious disease doc here in the Midwest. A close family member of hers was made healthier by this man and she felt I should at least see him. It took months to get in, and I was profoundly skeptical.

The day came and I brought my partner with me to help me express what was happening, ask smart questions, and remember it all. When you lose your words and you forget things the way I do, you stop going to appointments alone. You stop going anywhere alone.

When he walked in, I knew right away something was different. He told me he was allowing two hours for our visit. I’d never had more than minutes with any doctor. He asked me questions about my current life, and my past. In many cases, before I could answer he’d tell me what he suspected my answer was going to be. He was always right.

He explained his research into Fibromyalgia and Chronic Fatigue Syndrome and how it had become his driving passion for many, many years. He spoke to us about his research, the two papers he’d published and the third on which he was currently working.

“I am 95% positive, Sher, that when we test your urine you will be positive for mycotoxins – black mold.”

In my life, no doctor has made such a bold statement. No physician of any kind had ever before been so confident to use such language BEFORE tests.

“It’s with good reason that you tell me you know you are dying. That’s exactly what is happening. The mycotoxins are killing you at a cellular level.”

And, then he said two little sentences that changed everything.

“I can help you. I will help you.”

I cried, and when at the end of our time together he got up to leave he opened his arms wide to me. “Around here, we give hugs.”

I came home and prayed that I’d be positive for black mold. There’s a prayer I never imagined.

When the tests came back, about two weeks, I received a copy of my results. There it was in black and white. Black mold. Mycotoxins. “You have a black mold factory living in your sinus cavity, Sher,” doctor said.

It could have begun as a very young girl in the South. It could have happened all the years I lived in Kentucky. It could have been in Germany. It definitely could have been made worse again by all the flooding and old homes in Southeast Kansas.

“You don’t have to be living in a home with black mold on the walls to have this happen to you,” he said.

That’s been several weeks ago now, and every day I take the treatment he’s prescribed. It amounts to inhaling a drug to kill the mold. There is no way to know how long it will take, but I don’t care. If it takes a year I’ll do it every day and wait for this to be over. The only side effects I’m currently having are that I’m so nauseous almost all the time now, and the fatigue has gotten even worse… if you can imagine such a thing.

I’m waiting on a call from his nurse right now about those things, but I’ve told myself the nausea is from the treatment running down my throat to my stomach. And the worsening fatigue? Well, I used to tell my babies that when your body is working hard to make you well, you have to rest because it takes so much energy for healing. There is a war inside my body now and I’m just going to have to do the best I can to wait it out.

At least we know what the hell this invisible, torturous monster is and there is hope now. I want to be healthy again. I want to take my grandmonkeys on outings. I want to run. I want to drink coffee in Portland, and sleep in a treehouse in New England, and drink great wine with friends in Chicago, and eat the best pizza in New York, and zipline in some place lush and warm. I want to be me again.

I have two incredibly loving and supportive children and a man in my corner who says things like, “I’d rather have life with you – even when you’re not well – than life without you. No question.”

Can’t quit now. I’m three feet from sunshine.

If you’re wondering about black mold poisoning, I’ll leave you with the following information:


Please note that this is an exhaustive list. You do not have to have every single symptom to have a mold related illness.

  • Abdominal pain
  • Aches and pains
  • Aggression and other personality changes
  • Anxiety
  • Bleeding gums
  • Bleeding in the brain
  • Bleeding tendency
  • Blood not clotting properly
  • Blurry vision and vision worsening
  • Bone marrow disruption
  • Brain fog
  • Burning sensation in the mouth
  • Chest pain
  • Chronic fatigue
  • Cold or flu type symptoms or recurring colds
  • Coma
  • Confusion
  • Coughing
  • Crawling skin
  • Damage to heart
  • Death
  • Depression
  • Dermatitis
  • Diarrhea
  • Difficulty breathing
  • Difficulty concentrating and paying attention
  • Disorientation
  • Dizziness
  • Drowsiness
  • Eye damage
  • Eye inflammation and soreness
  • Fever
  • Hair loss
  • Hallucinations
  • Headaches
  • Hearing loss
  • Heart inflammation
  • Hemorrhage – internal bleeding
  • Immunosuppression
  • Impaired learning ability
  • Infections reoccurring
  • Irregular heartbeat
  • Itchy nose
  • Jaundice (yellowing of the eyes & skin)
  • Joint pain
  • Joint stiffness
  • Liver disease
  • Low blood pressure
  • Malaise
  • Memory loss and memory problems
  • Muscle pain
  • Nausea
  • Nose bleeds
  • Numbness
  • Pulmonary edema
  • Pulmonary hemorrhage
  • Red or bloodshot eyes
  • Runny nose
  • Seizure
  • Sexual dysfunction
  • Shaking
  • Shock
  • Shortened attention span
  • Slowed reflexes
  • Sore throat
  • Stuffy, blocked nose
  • Tingling
  • Trembling
  • Vomiting
  • Vomiting up blood
  • Weakness
  • Weight loss, anorexia
  • Wheezing
    Sharing is Caring…!



An Advanced All-Natural Guide to Treating Crohn’s Disease and IBD-Term life

These days it seems like almost everyone has a problem with their stomach of some sort or another. Part of it is the food we eat, part of it is the nutrients we lack, and a lot of it has to do with stress.

But the first part is figuring out what exactly is going on with your digestion.

Is It IBS, IBD, Crohn’s, Ulcerative Colitis, or Something Else Entirely?

Stomach problems are often very difficult to diagnosis correctly because they tend to all have similar symptoms. Abdomen pain and cramps, loss of appetite, weight loss, fatigue, and diarrhea are all common in people with all sorts of different conditions.

Here are some general ideas to help you figure out what you have going on, though I would highly recommend also talking to your doctor.

Crohn’s Disease

Crohn’s is actually a form of Inflammatory Bowel Disease (IBD) and affects the walls of the small and large intestine, though it can also affect your mouth, stomach, rectum, and anus. It usually appears in patches and lesions and can affect the entire thickness of the bowel walls.

Crohn's 3

The symptoms vary a lot from person to person but often include: constipation or diarrhea (usually non-bloody), low-grade fevers, abdominal pain, loss of appetite, gas, bloating, fatigue, black stools, and weight loss.

A lot of factors can contribute to the development of Crohn’s disease from eating too many saturated fats, refined carbohydrates, and sugar to eating too few fruits and vegetables. Smoking, antibiotics, infections, stress and nutritional deficiencies can also all play a role.

Ulcerative Colitis

Ulcerative colitis is similar, but the damage is usually just in the large intestine and rectum, and affects only the innermost layer of the walls.

How to Help Control and Improve Your Symptoms

Because Crohn’s is caused by inflammation, the main idea to relieve symptoms is to somehow control that inflammation.


The First Thing You Can Do…

The first thing you need to do is to try to identify and remove any triggers. While people react differently to different foods, you should start with the most common food allergies.

allergy foods


Eliminating wheat and all other grains containing gluten is a good place to start because they have been shown to increase inflammation and mess up your gut flora.


Dairy contains antibiotics and hormones that can alter your gut flora and make them start inflaming your whole gastrointestinal tract.

Refined Sugar

Studies have shown that if you eat a lot of refined sugar, you are more likely to get IBD.


Carrageenan is often used as a stabilizing agent in milk products. Animal studies have shown that eating too much of it can lead to ulcerative colitis. Studies in humans have yet to prove the same thing, but it could definitely be making the inflammation worse.

The Second Thing You Can Do…

The second thing you can do is start eating more fruits, vegetables, and dietary fiber. Brassica vegetables, onions, and garlic can all help to increase antioxidant levels and decrease inflammation.

Drinking plenty of water is also key to keeping your bowels healthy. Especially if you already drink coffee, you should make sure to drink at least 1-2 liters of water a day.


Certain herbs are great for helping treat IBD because of their anti-inflammatory properties.


Turmeric has been used in cooking around the world for centuries. It contains curcumin, which has powerful anti-inflammatory properties. In particular it helps to fight cytokines, which cause inflammation, and modulates pathways which decrease inflammation.


Studies have shown that giving curcumin to patients with Crohn’s and colitis can significantly improve their symptoms.


Quercetin is actually a bioflavonoid, which sounds complicated, but all you need to know is that it’s an antioxidant that can decrease inflammation by lowering the amount of histamine that your body releases. Plus, it can help slow down leukotrienes, which can make inflammation worse.

Quercetin can be taken as a supplement or you can simply eat more fruits and vegetables, especially citrus fruits.


Studies have shown that the yeast, Sacharomyces boulardii, is a very safe and effective treatment for patients with Crohn’s disease, helping decrease diarrhea, intestinal inflammation, and the risk of relapse.

Lactobacillus, another probiotic bacteria, has also been shown to be beneficial in Crohn’s patients, especially in children.


Stress is a major trigger for IBD attacks so you should pay special attention to your daily stress levels.

Yoga, meditation, setting boundaries, and making time for yourself are all great ideas for relieving stress. One of the best things I tell my patients is find whatever it is that you enjoy, that helps your body and your mind calm down, and invest time daily into that activity, even if only for a few minutes a day.


Crohn’s (and Colitis) tends to make your body worse at absorbing certain nutrients because of the damage it does to your intestines. People suffering from IBD can be deficient in any of the following nutrients:

– Vitamin B12

– Iron

– folate

– magnesium

– zinc

– potassium

– calcium

– Vitamin A, C, E, D, or K

If you suffer from IBD, speak to your health care provider to see which supplements may be best for you to increase your vitamin and mineral intake.

Please note: Inflammatory Bowel Disease (Crohn’s and Colitis) are very serious conditions. Please talk to your health care provider before taking any medications and supplements to see which may be the safest and best suited for you.