This man suffers with a severe case of Parkinson’s disease. Watch what happens when he first takes cannabis.
First Showed On Unilad Facebook Page Via Ride With Larry
Source: Unilad (facebook.com)
This man suffers with a severe case of Parkinson’s disease. Watch what happens when he first takes cannabis.
First Showed On Unilad Facebook Page Via Ride With Larry
Source: Unilad (facebook.com)
Anavex Life Sciences Corp. will receive funding for a phase 2 trial of its Anavex 2-73 drug from the International Rett Syndrome Foundation to study the rare neurological disorder, the company announced early Thursday.
The $600,000 grant, which will fund the majority of Anavex’s AVXL, -0.71% clinical trial, will be the fifth clinical trial for Rett syndrome funded by the foundation and underway this year. Other biotech companies with funded trials include Neuren Pharmaceuticals Ltd. NEU, +8.20%
Rett syndrome is a rare condition affecting about one in 10,000 girls that’s caused by a mutation on the X chromosome. Symptoms include motor and cognitive impairments, seizures and anxiety, and many of those affected die young.
Many in the Rett syndrome community are looking in the long term to gene therapy for a treatment. But having a drug that works across the broad spectrum of symptoms — as opposed to taking medications for each one — is a more near-term goal, said Gordy Rich, the Rett foundation’s chief operating officer.
Rich is also a Rett parent. The prospect of a more comprehensive medication for his 22-year-old daughter is “life-altering,” he said.
“When my daughter was diagnosed there was no known cause and no known cure,” Rich said. Five clinical trials being underway means “to all parents, this is really the most incredible time… We’ll have options for our girls that can improve their quality of life.”
Anavex 2-73, which was designated as an orphan drug for Rett syndrome last spring — which grants companies developing rare diseases various development and commercial incentives— may have that potential.
The 12-week trial — which will cost about $1 million total and enroll between 50 and 80 patients — will measure the drug’s effect on seizure reduction, cognitive impairment, mood disorder, autistic behavior and anxiety, Christopher Missling, president and chief executive officer of Anavex, told MarketWatch.
The drug was selected based on its results in mice, where it addressed a number of symptoms, Rich said.
“To us that’s very exciting, and we want to move as many of the compounds into clinical trials so we can get treatments on the path to a cure,” he said.
The trial is expected to begin this year, with data possibly coming out by the end of the year, Missling said.
Anavex’s relationship with the foundation will also assist in enrolling patients in the trial, which should help hasten trial results, he said.
Anavex 2-73 is also being tested in other areas, including Alzheimer’s disease, Parkinson’s disease, autism and more.
By RONI CARYN RABIN
Parkinson’s disease, a chronic, progressive movement disorder characterized by tremors and stiffness, is not considered a fatal disease in and of itself, though it may reduce life expectancy by a modest amount. It is often said that people die “with” Parkinson’s rather than “of” the disease.
“People who are healthy when diagnosed will generally live about as long as other people in their age cohort,” said James Beck, the vice president for scientific affairs at the Parkinson’s Disease Foundation, which is involved in research, education and advocacy. “It is not a death sentence.”
Since Parkinson’s generally affects people later in life — patients are typically given a diagnosis in their 60s — patients often die of unrelated age-related diseases like cancer, heart disease or stroke. But the most common cause of death in those with Parkinson’s is pneumonia, because the disease impairs patients’ ability to swallow, putting them at risk for inhaling or aspirating food or liquids into their lungs, leading to aspiration pneumonia.
Since Parkinson’s also impairs mobility and balance, those with the disease are also at high risk for falls and accidents, which can trigger a cascade of medical problems, including being bedridden and developing pneumonia, Dr. Beck said. In its advanced stages, the disease can make walking and talking difficult and cause other problems not related to movement, including cognitive impairment. Patients often cannot care for themselves and need assistance carrying out simple activities of daily living.
One long-term study followed a group of 142 Parkinson’s patients after they were given their diagnosis; their mean age at diagnosis was around 70. The researchers found that 23 percent were generally doing well 10 years later, meaning they could maintain their balance and did not have dementia. But over half of the patients in the original group had died, with the most common cause related to Parkinson’s being pneumonia. The probability of losing one’s ability to maintain balance after 10 years was calculated to be 68 percent, and the probability of developing dementia was around 46 percent.
By Alice Park
It took nearly six months but the General Medical Council (GMC) in the U.K. has pulled Dr. Andrew Wakefield’s license to practice medicine in the United Kingdom.
Wakefield is the researcher who nearly single-handedly fueled parental concerns about the link between vaccines and autism. In 1998, he published a paper in the medical journal Lancet describing eight children who showed signs of autism within days of being inoculated for measles, mumps and rubella. A gastroenterologist by training, Wakefield went on in further studies to suggest that the virus from the vaccine was leading to inflammation in the youngsters’ guts that then impeded normal brain development.
Further investigations by other researchers in the decades since have failed to confirm his claims, and in January, the GMC ruled that Wakefield had acted “dishonestly and irresponsibly” in conducting the experiments that led to the publication of the paper. According to the BBC, among his alleged acts of misconduct were conducting those studies without ethical approval of the hospital at which he practiced, and paying children at his son’s birthday party for blood samples. He also served as a paid consultant to attorneys of parents who believed their children had been harmed by vaccines.
In February, editors of the Lancet retracted Wakefield’s controversial paper, telling the Guardian “It was utterly clear, without any ambiguity at all, that the statements in the paper were utterly false.”
Defending his career on the Today show on Monday, Wakefield, now in the U.S., vowed to appeal the decision and maintained that “there are millions of children out there suffering, and the fact [is] that the vaccines cause autism.” Without a license to practice medicine, and the growing evidence to the contrary, it’s going to harder for him to prove that claim.
A physical therapist who read about the health benefits of music decided to incorporate it into a session with one of her patients who has Parkinson’s disease, and posted the remarkable results online. Anicea Gunlock’s video features her patient, identified only as Larry, who goes from struggling to walk with the aid of a walker to leading Gunlock in a dance by the end of the clip.
“I don’t know who was more shocked at the immediate results!” Gunlock posted with the Jan. 5 video, which has amassed 8.4 million views.
Symptoms of Parkinson’s disease vary from person to person but can include tremor, slowness of movements, limb stiffness and difficulties with gait and balance, according to the National Parkinson Foundation. Severity of the disease can be broken down into five stages, and there is no known cure.
Gunlock told Fox 13 that Larry’s wife followed them around the house crying tears of joy over his progress.
“She said she had been praying for a miracle for her husband and truly felt like this was an answered prayer,” Gunlock told Fox 13.
The video captures nearly four minutes of Larry’s progress, but Gunlock said he continued to walk for 15 minutes more, even singing along to the country song that she had chosen.
“I have never seen results of this magnitude this quickly before and by the end of the session we were all in tears but they were definitely happy tears,” she said.
Pembinaan Lebuh Raya Pesisiran Pantai Barat yang sepanjang 233 kilometer dari Banting, Selangor ke Taiping, Perak melalui persisiran pantai Barat yang berdekatan dengan Pekan Beruas, Simpang Empat, Hutan Melintang dan lain-lain pekan yang sehala menuju ke Banting. Projek ini banyak memberi manfaat kerana ia dapat memendekan masa perjalanan untuk ke Kuala Lumpur dan dapat mengurangkan kesesakan lalu lintas di kawasan tertentu pada musim perayaan.
Lebih menarik lagi, Lebuh Raya Pesisiran Pantai Barat ini bakal menghubungkan bandar seperti Banting, Shah Alam, Kuala Selangor, Tanjung Karang, Sabak Bernam dengan Teluk Intan. Projek dengan kos RM6 bilion ini sudah bermula sejak 2014 lagi dan kini, kita sudah boleh nampak kerja-kerja pembikinan sedang giat dijalankan hampir di seluruh kawasan yang terlibat. Dikatakan, Lebuh Raya ini akan dikenakan kutipan tol apabila dibuka pada 2019 nanti.
Tan Sri Dato’ Haji Muhyiddin bin Yassin bekas timbalan perdana menteri Malaysia telah merasmikan projek infrastruktur mega ini pada 25 Mei 2014 yang akan merancakkan lagi pembangunan kawasan sekitar jajarannya, termasuk di Teluk Intan. Beliau yang merasmikan majlis pecah tanah projek berkenaan berkata, pembinaan lebuh raya yang memakan masa lima tahun itu membuktikan keprihatinan kerajaan dalam mengatasi masalah rakyat yang berdepan kepadatan trafik di Lebuh Raya Utara-Selatan (PLUS) terutama pada musim cuti atau perayaan.
Dianggarkan lebih 22,000 peluang pekerjaan telah diwujudkan untuk penglibatan kerja-kerja pembinaan lebuh raya itu, manakala antara 2,000 hingga 3,000 tenaga kerja kekal apabila laluan lebuh raya ini siap dibina 2019 nanti.
Lupus is a chronic autoimmune disease that can damage any part of the body, from the skin to the joints through the organs. It is a disease that acts by outbreaks and then seems to disappear before returning again.
But researchers say they have discovered that by using a combination of two drugs already exist, it is possible to reverse the effects of lupus in mice.
In a new study published in Science Translational Medicine, researchers at the University of Florida, Gainesville, have discovered that by inhibiting certain metabolic pathways in immune cells that can fight lupus in mice. Researchers at UF Health may have found a way to control lupus changing the way the immune system cells use energy.
“The most surprising result of this study was that the combination of the two metabolic inhibitors were needed to reverse the disease.” Dr. Laurence Morel, University of Florida College of Medicine
Systemic lupus erythematosus or lupus, is an autoimmune disease in which the immune system that is supposed to protect the body against foreign invaders – attacks the body’s own tissues, causing inflammation. Lupus can sometimes have symptoms similar to arthritis.
One of the markers of lupus are CD4 T cells (white blood cells that activate other immune cells). For people with lupus, the metabolism of T cells is overactive. T cells activated involve hyper- increased inflammation, and this means more physical damage. When researchers blocked glucose metabolism by using an inhibitor of glucose, metformin (common treatment in type 2 diabetes), CD4 T cells return to normal activity (metabolism CD4 slows down) and lupus symptoms were reversed. “If the T cell is normal, the disease gets better,” Morel said.
The research team initially had the idea of using a two-pronged attack on lupus after seeing a similar approach in research in cancer, said Dr. Laurence Morel, director of experimental pathology and professor of pathology, immunology and medicine laboratory in the UF College of Medicine.
“If it works to limit the metabolism of cancer cells, should work to limit metabolism in T cells,” said Dr.Morel.
The efficacy of metformin in restoring normal function of T cells when studied in the laboratory is also bode well for potential future application for the treatment of patients with lupus.
“That suggests that metabolic inhibitors can also be used to treat patients,” Morel said. “It’s the first time has shown that it can have an effect on the symptoms and manifestation of lupus by normalization of cellular metabolism.”
The two used in research in this study drugs were shown to inhibit the metabolic pathways before, but the combination seems to be the key to success.
“The most surprising result of this study was that the combination of the two metabolic inhibitors were needed to reverse the disease, when they could have predicted, based on models published by other people that one would work,” said study co-author ,
Dr.Laurence Morel, director of experimental pathology and professor of pathology, immunology and laboratory medicine at the University of Florida College of Medicine.
Among other researchers who worked on the project are: Dr. Eric S. Sobel, associate professor of rheumatology and clinical immunology professor; Dr. Byron P. Croker, a professor of renal and surgical pathology; and Dr. Todd Brusko, assistant professor in the UF Diabetes Institute, department of pathology, immunology and medical laboratory.
Their research was funded by grants from the National Institutes of Health and the Alliance for Lupus Research. The human trial will be made in September 2015, favorable results are expected since the tests in mice was a success.
Did you know that down through the centuries thyme has been used for many ailments, from influenza to epileptic seizures? It was often mixed with equal parts of lavender and sprinkled on the floors of churches in the Middle Ages to eliminate any unwanted odors. Long before the discovery of modern medicine, crushed thyme was placed on bandages to promote wound healing and ward off infection.
The volatile essential oils in thyme are loaded with anti-rheumatic, anti-parasitic, anti-septic, anti-viral, and anti-fungal properties.
If taken on a regular basis it can significantly help to reduce the viral load in the body which makes it very beneficial in dealing with Chronic Fatigue Syndrome, Fibromyalgia, Hashimoto’s Thyroiditis, Rheumatoid Arthritis, Lupus, Vertigo, Tinnitus, and Multiple Sclerosis.
Thyme is packed with vitamins and minerals. It’s rich in potassium, iron and calcium, all of which contribute to blood pressure regulation, proper red blood cell formation and distribution of antioxidants in the body. It is rich in high in B-complex vitamins, vitamin A, C and folic acid. Thyme contains a variety of important bioflavonoids and volatile oils, including thymol. Thymol is an essential oil that has very powerful antioxidant properties.
Thyme has cancer preventive properties; containing terpenoids like rosmarinic and ursolic acids. (Regular consumption of thyme has been shown to increase the amount of DHA (docosahexaenoic acid, an omega-3 fatty acid) in brain, kidney, and heart cell membranes)
Thyme’s essential oils have expectorant and bronchial antispasmodic properties treating…
How to make Thyme Tea, Instructions.
1) Put some herbs in your brewing container – about 1 tsp dried herbs per cup of water. For fresh herbs, use more.
2) Pour over water that’s just off the boil.
3) Cover and infuse for about 5 minutes.
4) Strain and serve.
When we talk about autism, we often speak seriously. And it’s no wonder why: autism is a serious disorder that is associated with many strengths but also many challenges. Let’s face it, though: people with and without autism are funny, and we can all get a real riot out of all the universal things we tend to think, say, and do. And everyone with autism may be different, but because it is characterized bydiffering degrees of social struggles, communication difficulties, and repetitive behaviors, there are plenty of familiar experiences out there that unite people touched by autism and make them say: “That’s so true!”
So to lighten up things a little bit and laugh about our lives, we asked you to finish this sentence: “You might be an autism parent if…” We got so many funny and heartwarming responses, we couldn’t resist sharing these 21 of them with you (number 19 is, without a doubt, my favorite. I’m not ashamed to say I laughed out loud!).
(Note: Posts have been edited for grammar.)
Your son has shirts of all his favorite TV characters but spends most of his time in only underwear… –David W.
You have to stand and wait for a door to close just so your child can open it themselves! –Becky M.
Your child is terrified of noise but is one of the loudest people you’ve ever met! Love him though! –Corrina B. B.
Forgetting the iPad is considered an “emergency!” –Miranda W.
Your son’s teacher tells you he corrected her in front of the whole class when she got some facts about the Titanic incorrect! –Michaela L.
Your child loves to eat French fries but won’t eat mashed potatoes even though you explain and show him that it’s French fries, just mashed… –Rebecca F. L.
Your child has absolutely no concept of time whatsoever. Freaks out if late for something but moves as slow as molasses. –Robin S. L.
Gently shampooing your toddler’s hair causes the police to think that a murder is going on in your bathroom! –Bonnie S.
You have an entire conversation that consists of nothing but lines from his favorite movies. –Jeannie P.
Your son can construct the Eiffel Tower out of Legos but never wants to leave the house to see it in person. –Angela C. B.
You’re standing less than three feet away, calling their name, and they ignore you, but when Mickey Mouse comes on the TV upstairs, they race off to watch it. –Belinda S.
You say things like “Stop licking the porch” or “Quit drinking the pool water.” –Patricia L. B.
Your daughter can tell you in detail the mummification process but can’t tell you why she walked outside. –Melissa L.
Your heart swells with pride because your child has plucked up the courage to say “hi” to a friend you unexpectedly meet when you are out. –Theresa T.
Your five-year-old son spins in the same spot for 20 minutes and doesn’t get dizzy. –Cynthia P.
Your child doesn’t comprehend mockery but is a Master Mocker of all sounds, including car wheels, animals, and electronics. –Janelle A.
The main item on your shopping list is ketchup. –Anne C.
Your child draws squares on his schoolwork papers and writes, “Put the A here” for his teacher. –Kathleen G. M.
You get overly excited for a random hug, kiss, or sign of affection. –Jes L.
The love you felt when they placed him/her in your arms for the very first time and it is still there 30 years later when they do something on their own and are so proud of it! –Anna T. N.
By Craig Richard
A brave young girl living with a rare condition was serenaded by her musical hero at her hospital bedside today.
Nine-year-old Melody Driscoll has Rett Syndrome, a condition that affects brain development and causes physical and mental disability, and is often an inpatient on Casey Ward – the children’s ward at Epsom Hospital.
During long stays in hospital there’s always one thing certain to brighten Melody’s mood – flame-headed singer-songwriter Ed Sheeran.
Her parents launched a campaign for her to meet Ed, and today (Wednesday, November 9), he obliged.
Ed signed Melody’s pink guitar before treating her to two of his hits, Thinking Out Loud and Photograph, before posing for snaps and meeting other young inpatients.
Dr Ruth Charlton, Consultant Paediatrician and Joint Medical Director, said: “We are so touched that Ed would take the time out of his busy schedule to visit Melody and the other young patients on the ward.
“Melody was mesmerised by Ed, and it was a truly wonderful to see how happy he made her.
“We would like to thank Ed for coming – this was a very special day for our staff, our patients and of course, Melody.”
Melody’s mum Karina, (pictured above with Dr Charlton and Ed Sheeran), who launched the campaign, said: “Melody absolutely loves Ed’s music, and his lyrics mean so much to us as a family. It was amazing to meet Ed, and everyone could see just how impressed Melody was – she even got hugs and kisses from him!
“We joke that Ed is Melody’s boyfriend because she is so taken with him, and now that she’s met him in person a dream has come true.
“Ed’s music and the staff here, including Melody’s consultant Dr Tim Marr, have kept her alive.”
Ward Manager Karen Kilday, said: “It was wonderful to see Ed on the ward and to see the joy that it brought to Melody. His caring and relaxed approach were evident to see and everyone on the ward that day will remember the visit and this lovely moment forever.”